These tiny particles act as essential mediators of intercellular communication within the body. Unlike traditional skin care products that typically work on the skin’s surface, exosomes can penetrate deeply into the skin’s layers delivering bioactive compounds directly to targeted cells. Exosomes have the potential to stimulate various regenerative processes within the skin, promoting cellular repair and tissue regeneration, collagen production, and overall skin rejuvenation. They also modulate inflammatory responses which results in decreased downtime when paired with other procedures. Exosomes can be used as a substrate for microneedling or as an add on after procedures such as CO2 skin resurfacing and radio frequency microneedling. When paired with these procedures not only will they decrease healing time and downtime but will also enhanace the procedure’s results.